ALZHEIMER'S DISEASE AND ITS NEW FORM, ApoE4: NEW APPROACHES AND RESEARCH PROSPECTS UNTIL THE END OF 2024

Alzheimer's disease is the most common cause of dementia and has received significant attention from researchers in recent decades, particularly due to the ApoE4 gene variant.ApoE (apolipoprotein E) is a protein to bulk large in lipid metabolism and maintaining neuronal health.The ApoE4 variant is the greatest genetic risk factor for developing Alzheimer's disease and is associated with early onset and faster progression of the disease.

Differences from previous types

The genetic variant of ApoE4 influences the pathological mechanisms of the disease in different ways.While the formation of classic amyloid plaques and neurofibrillary tangles are the main features of the disease in earlier types of Alzheimer's, in the case of Alzheimer's caused by ApoE4, disruption of lipid metabolism and decreased communication between nerve cells has a key role as well.ApoE4 therefore not only promotes the accumulation of plaques, but also contributes to the increase in inflammatory processes, which aggravate neuronal damage.

Research outlook until the end of 2024

Alzheimer's research for 2024 shows several exciting directions. The latest studies aim to gain a deeper understanding of the effects of ApoE4, with a particular focus on:

1. Development of biomarkers

For ApoE4 carriers, biomarkers are being developed for early diagnosis, which may help identify the early stages of the disease.

2. Targeted Therapies

Researchers are developing new drug treatments that specifically target the pathological processes caused by ApoE4. Immunotherapies and gene therapies are promising ways.

3. Lifestyle interventions

Lifestyle changes, such as diet, exercise, and mental activity, aimed at preventing Alzheimer's disease and slowing its progression have also received more attention.

4. Clinical Trials

Clinical trials for the treatment of ApoE4 carriers are testing a number of new drugs and treatment protocols to understand how to better influence the course of the disease.

Overall, understanding the new ApoE4 form of Alzheimer's disease is essential for more effective treatment and prevention of the disease.Research is on going, and future findings could greatly contribute to improving the quality of life for patients.In the near future, over the next few years, further discoveries are expected that may offer new hope for patients and their families.